The High Priest of Ptah was sometimes referred to as the Greatest of the Masters of the Craftsmen (wer kherp hmww). This title refers to Ptah as the patron god of the craftsmen.

The office of the High Priest of Ptah was located in Memphis in Lower Egypt. The temple of Ptah in Memphis was dedicated to Ptah, his consort Sekhmet and their son Nefertem.

High priests of Ptah are mentioned in inscriptions dating back to at least the Fourth Dynasty. In the tomb of the nobleman Debhen, for instance, there is a description of a visit by Pharaoh Menkaure to the construction site for his pyramid "Divine is Menkaure". The pharaoh is accompanied by a naval commander and two high priests of Ptah.

There used to be two high Priests of Ptah until the Sixth Dynasty. It was probably during the reign of Pepi I that the two offices were combined into one. In the tomb of Sabu called Thety in Saqqara, the owner mentions that "His Majesty appointed me as High Priest of Memphis alone. ___ The temple of "Ptah-South-of-His-Wall" in its every place was under my charge, although there never was a single High Priest of Ptah before."

A large temple complex dating to the time of Ramesses II is located at the modern site of Mit Rahina. The Temple of Ptah from this time period was one of the largest temple complexes in Egypt. Not much of this complex has been excavated because a large part of the site lies very close to the modern town.