Désiré-Félicien-François-Joseph Mercier (21 November 1851 – 23 January 1926) was a Belgian Cardinal of the Roman Catholic Church. He served as Archbishop of Mechelen from 1906 until his death, and was elevated to the cardinalate in 1907. Mercier is noted for his staunch resistance to the German occupation of 1914–1918.

He received his episcopal consecration on the following 25 March from Archbishop Antonio Vico, and took as his episcopal motto: Apostolus Jesu Christi.

Mercier was created Cardinal Priest of S. Pietro in Vincoli by Pope St. Pius X in the consistory of 15 April 1907.

Pope Benedict XV sent his portrait and a letter of whole-hearted support to Mercier in 1916, and at one point told him "You saved the Church!"

He was also one of the cardinal electors in the 1922 papal conclave, which selected Pope Pius XI.

He is commemorated by this large bronze statue outside of St. Michael and Gudula Cathedral in Brussels.

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